Granulopoiesis During Myleran-induced Suppression of Transplantable Hematopoietic Stem Cells
نویسندگان
چکیده
منابع مشابه
In vivo generation of transplantable human hematopoietic cells from induced pluripotent stem cells.
Lineage-restricted cells can be reprogrammed to a pluripotent state known as induced pluripotent stem (iPS) cells through overexpression of 4 transcription factors. iPS cells are similar to human embryonic stem (hES) cells and have the same ability to generate all the cells of the human body, including blood cells. However, this process is extremely inefficient and to date has been unsuccessful...
متن کاملPlenary Paper In vivo generation of transplantable human hematopoietic cells from induced pluripotent stem cells
1Harvard Medical School, Boston, MA; 2Harvard Stem Cell Institute, Boston, MA; 3Department of Hematology/Oncology, Beth Israel Deaconess Medical Center, Boston, MA; 4Department of Laboratory Medicine, Joint Program in Transfusion Medicine, Children’s Hospital, Boston, MA; 5Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA; and 6Cancer Science Instit...
متن کاملIn vitro maintenance of highly purified, transplantable hematopoietic stem cells.
The cellular and molecular mechanisms that regulate the most primitive hematopoietic stem cell are not well understood. We have undertaken a systematic dissection of the complex hematopoietic microenvironment to define some of these mechanisms. An extensive panel of immortalized stromal cell lines from murine fetal liver were established and characterized. Collectively, these cell lines display...
متن کاملDifferentiation of Mouse Embryonic Stem Cells into Hematopoietic Cells
Purpose: Differentiation of Mouse embryonicstem cells into Hematopoietic cells. Materials and Methods: In this study, we used EB formation system for Hematopoietic differentiation of mouse embryonic stem cell (Royan B1) in suspension culture. EBs cultured in medium with Hematopoietic inducer cytokines (SCF, TPO, GMCSF, IL3, Flt3 and EPO) .presence of hematopoietic differentiated cell assessed ...
متن کاملMicroRNA Modulation during the In vitro Culture of Hematopoietic Stem Cells Prior to Transplantation
Background: Human umbilical cord blood (HUCB) is an acceptable and readily accessible source of stem cells. There is an ongoing interest in cord blood stem cell therapies; however, little is known about the possible unfavorable effects of laboratory modifications on the isolated HUCB cells. The involvement of miRNAs in several biological processes has been shown. The aim of this study was to ev...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Blood
سال: 1972
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v39.3.317.317